Colin Selman
Biogerontologist who studies how diet and nutrient-sensing pathways such as insulin/IGF-1 and mTOR set the pace of ageing
Professor of Biogerontology · Head of School of Molecular Biosciences · University of Glasgow
School of Molecular Biosciences, University of Glasgow (Glasgow, Scotland, United Kingdom) ↗
Colin Selman is Professor of Biogerontology and Head of the School of Molecular Biosciences at the University of Glasgow. His research covers ageing, dietary restriction, insulin/IGF-1 and mTOR signalling, mitochondria and frailty.
He studied zoology at Glasgow and earned his PhD at Durham University on how a migrating shorebird changes its metabolism. Postdoctoral work in Aberdeen, at the University of Florida and at Imperial College and UCL moved him towards metabolism and ageing. He lectured at Aberdeen from 2007 and returned to Glasgow as professor in 2013.
In the Atlas he is first author of SEL2009 in Science. Mice lacking S6K1, a kinase directly downstream of mTORC1, lived longer and stayed healthier in old age. The lifespan gain (about 19% median) was clear in females but not significant in males.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2009 | A | Ribosomal protein S6 kinase 1 signaling regulates mammalian life span SEL2009 First author: deleting S6K1 extended median lifespan in female mice (not significant in males) and protected against age-related decline (mice). |
Co-authors in the Atlas
People with a profile here who share at least one study with Colin Selman.
- Dominic J. Withers Studies how hormone and nutrient signaling pathways control metabolism and ageing, including the finding that loss of S6K1 extends lifespan in mice.
- George Thomas Purified and cloned S6K1, the kinase that became the classic readout of mTORC1 activity. His lab later showed that mice lacking S6K1 resist diet-induced obesity, and that amino acids signal to mTORC1 through the lipid kinase hVps34 (GUL2008)
- Linda Partridge Showed that rapamycin extends fruit-fly lifespan through TORC1, via autophagy and reduced protein synthesis, and that it adds benefit even on top of dietary restriction
- Sara C. Kozma Studies the S6K/mTOR pathway and how it controls cell growth, ribosome production, diabetes and cancer, including mTOR signalling in liver cancer.
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