Aubrey M. Sills
Researcher at the Barshop Institute in San Antonio who worked with common marmosets in Adam Salmon's group and led the 2018 study of long-term rapamycin and blood health in these small primates
Barshop Institute for Longevity and Aging Studies, UT Health San Antonio (papers 2018–2020; at the time of the study)
Aubrey Sills was first author of the 2018 Atlas study (SIL2018), with Adam Salmon as senior author, that gave middle-aged common marmosets rapamycin every day for nine months. Marmosets are small, relatively short-lived monkeys, which makes them useful for testing anti-aging drugs in a primate. Rapamycin blocks mTOR and extends life in mice, and the study asked whether long-term use is safe for the blood system of a primate. In the marmosets, routine blood tests changed only a little. Females had lower rapamycin levels in their blood than males, yet both sexes showed few changes. The authors concluded that blood side effects are unlikely with long-term rapamycin in healthy middle-aged animals of this kind. This is a primate study, not a human one.
Sills also co-authored a 2020 paper in GeroScience from the same institute, with Veronica Galvan and Adam Salmon, that described a method for growing nerve cells and astrocytes from newborn marmoset brains, as a primate model for studying brain aging in a dish. No personal page was found, so the affiliation shown is the one on these papers.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2018 | A | Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. SIL2018 First author: reported that nine months of daily rapamycin caused only minor changes in blood counts in middle-aged marmosets. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Aubrey M. Sills.
ShowHide
- Adam B. Salmon Biologist of aging at UT Health San Antonio whose work in this Atlas spans rapamycin in mice and in common marmosets. He is a co-author on the Interventions Testing Program reports from the San Antonio site and on the marmoset rapamycin studies on blood markers, epigenetic age and the salivary gland
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.