mTOR Academy
mTOR Core
Ten lessons that build the mental model most mTOR papers assume you already have: what the kinase integrates, why it works as two different complexes, how a small GTPase and its brake decide when it fires, and where the field's own evidence stops.
New to this? What you need first — seven terms and six questions to check yourself against.
New here: go in order, Part I then II then III. Each part leans on the one before it, so skipping ahead makes Part II hard to follow.
Already comfortable with the mechanism? Lesson 10 (how to read an mTOR paper) and the Research Challenges lab are the highest-leverage entry points here — treat the rest as reference and dip in where a gap shows up.
- Part IThe machineWhat is this kinase, and what switches it on?By the end of this part you can tell the two complexes apart, follow a small GTPase and the brake that holds it, and say where in the cell the switch is actually thrown.
- ○01What is mTOR?
- ○02mTORC1 vs mTORC2
- ○03Rheb — The Critical Regulator
- ○04The TSC Complex — Where the Inputs Meet
- ○05The Lysosome as a Signalling Platform
- Part IIInputs and outputsWhat does it listen to, and what does it do about it?By the end of this part you can trace a nutrient or a hormone from outside the cell to a readout, and say which input a single measurement leaves undecided.
- ○06Nutrient Sensing
- ○07Growth Factor Signalling
- ○08Feedback Regulation
- ○09mTOR and Autophagy
- Part IIIReading the evidenceHow do I tell what to believe?By the end of this part you can read a claim against the method behind it, name the tier of evidence it rests on, and say what the result leaves open.
- ○10How to Read an mTOR Paper
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