Pathway link TSC-RHEB

TSC1/TSC2 ⊣ Rheb

TSC1/TSC2 inhibits Rheb.

TSC2 forces Rheb to switch itself off – the one step where TSC acts as a tumour-suppressing brake.

TSC2 is a GAP for Rheb: it forces Rheb to hydrolyse its GTP, switching it off. This is the single step where the tumour-suppressor function lives.

The conditions it holds under

In vitro, Drosophila and mammalian cell biochemistry (INOK2003, GAR2003). GAP activity is shown in cells and in vitro; not measured in human tissue by these sources.

Time it takes

seconds

Step

direct (one molecule acts on the other)

Measured in

mammalian cells

Where in the cell

lysosome

Reaches people?

plausible in people, not shown directly

How settled

settled in the literature

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

The source works as a GAP: it changes the GTP or GDP state of the target. The label says what that does to the target, not that the target is switched on or off everywhere.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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