Pathway link ROS-MTORC1

Reactive oxygen species → mTORC1

Reactive oxygen species activates mTORC1.

Oxidative damage can itself switch on mTORC1 through a chain of signals, closing a feedback loop that can turn a brief stress into a lasting one.

Oxidative stress activates a redox-sensitive PI3K–Akt–mTORC1–eIF4A cascade that selectively promotes cap-dependent translation of P-glycoprotein.

The conditions it holds under

One cell-line study in a multidrug-resistance context; whether the loop runs in normal physiology at these ROS levels is untested.

Time it takes

minutes

Step

indirect (through steps not drawn here)

Measured in

cell line

Where in the cell

cytosol

Reaches people?

not tested in people

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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