Pathway link RAG-TSC

Rag GTPases – TSC1/TSC2

Rag GTPases recruits TSC1/TSC2.

Without amino acids, the Rags bring the TSC brake to the lysosome.

When amino acids run out, the Rag GTPases also pull the TSC complex onto the lysosome, where it can switch Rheb off and help shut mTORC1 down.

The conditions it holds under

Mammalian cell lines under acute amino-acid withdrawal; the contribution of this route in tissues is not established. Single study.

Time it takes

minutes

Step

direct (one molecule acts on the other)

Measured in

mammalian cells

Where in the cell

lysosome

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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