Pathway link MTORC1-PGC1A

mTORC1 → PGC-1α / YY1

mTORC1 activates PGC-1α / YY1.

mTOR works together with a gene-activating team to switch on mitochondrial genes – a rare example of this pathway acting inside the nucleus rather than at the cell's outer edges. The direct interaction rests on a single study in this Atlas.

mTOR interacts with YY1 and is required for the YY1–PGC-1α complex to drive mitochondrial gene expression; rapamycin lowers both the transcripts and oxygen consumption.

The conditions it holds under

Single-study support in this corpus for the direct interaction; the downstream respiratory phenotype is better replicated than the binding itself.

Time it takes

hours

Step

direct (one molecule acts on the other)

Measured in

mammalian cells

Where in the cell

nucleus

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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