PGC-1α / YY1
Transcriptional complex through which mTORC1 drives mitochondrial gene expression.
The switch that builds power plants. The switch that builds power plants.
mTOR interacts with YY1 and is required for YY1–PGC-1α function; rapamycin lowers mitochondrial gene expression and oxygen consumption (CUN2007). One of the clearest cases of mTORC1 acting through transcription rather than translation.
TL;DR. PGC-1α / YY1 appears in 1 curated study in Oliver's mTOR Atlas: 1 at the molecular level (cells, biochemistry, structure). No study in people is recorded for it in the Atlas yet. It has 1 interaction in the curated pathway model.
In the pathway model
| Interaction | Mechanism | Evidence | Studies |
|---|---|---|---|
| mTORC1 activates PGC-1α / YY1 mechanism: binding · this link in full · on the map table | mTOR works together with a gene-activating team to switch on mitochondrial genes – a rare example of this pathway acting inside the nucleus rather than at the cell's outer edges. The direct interaction rests on a single study in this Atlas. mTOR interacts with YY1 and is required for the YY1–PGC-1α complex to drive mitochondrial gene expression; rapamycin lowers both the transcripts and oxygen consumption. mTOR interacts with YY1 and is required for the YY1–PGC-1α complex to drive mitochondrial gene expression; rapamycin lowers both the transcripts and oxygen consumption. Holds under: Single-study support in this corpus for the direct interaction; the downstream respiratory phenotype is better replicated than the binding itself. plausible in people, not shown directly · emerging, few independent studies | M | CUN2007 |
Evidence at a glance
| Evidence | What it means | Studies |
|---|---|---|
| M | Molecular — cells, biochemistry, structure | 1 |
No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.
Studies
| Year | Evidence | Study |
|---|---|---|
| 2007 | M | mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex CUN2007 Showed mTOR isn't just about building proteins - it also runs the cell's POWER plants. mTORC1 drives mitochondrial gene expression and oxygen consumption through a YY1-PGC-1alpha transcriptional program; block mTOR with rapamycin and mitochondrial output falls. Explains part of why mTOR inhibition reshapes metabolism. |
Related entities
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