Pathway link MTORC1-OXPHOS
mTORC1 Oxidative phosphorylation
mTORC1 activates Oxidative phosphorylation.
mTORC1 boosts how much energy mitochondria can produce, through both gene activation and protein-building. One mouse experiment points the other way – removing mTORC1 from fat tissue RAISED respiration – so this direction is not settled in a living animal.
The conditions it holds under
Effect size varies strongly by tissue; the transcriptional and translational arms have not been cleanly separated in vivo. OVERLAP (audit 2026-09-04): this edge and MTORC1-MITO assert overlapping biology from overlapping citations (CUN2007, MOR2013) at different tiers and different consensus levels. Read them together; they are not independent support.
- Time it takes
- hours
- Step
- indirect (through steps not drawn here)
- Measured in
- mammalian cells
- Where in the cell
- mitochondrion
- Reaches people?
- plausible in people, not shown directly
- How settled
- emerging, few independent studies
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2007 | M | mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complexCUN2007 Showed mTOR isn't just about building proteins - it also runs the cell's POWER plants. mTORC1 drives mitochondrial gene expression and oxygen consumption through a YY1-PGC-1alpha transcriptional program; block mTOR with rapamycin and mitochondrial output falls. Explains part of why mTOR inhibition reshapes metabolism. |
| 2013 | M | mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulationMOR2013 mTORC1 controls mitochondrial biogenesis and activity through 4E-BP-dependent translation. |
Points the other way
| Year | Evidence | Study |
|---|---|---|
| 2008 | A | Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respirationPOL2008 Adipose raptor knockout yields lean, metabolically protected mice, revealing mTORC1's role in fat metabolism. |
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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