Pathway link LEU-LARS

Leucine → LARS (leucyl-tRNA synthetase)

Leucine activates LARS (leucyl-tRNA synthetase).

One competing idea: the enzyme that loads leucine onto its transport molecule for protein-building doubles as the leucine sensor.

A competing model: the enzyme that loads leucine onto tRNA doubles as the leucine sensor, binding free leucine directly.

The conditions it holds under

Proposed before the Sestrin2 model and never cleanly reconciled with it.

Time it takes

seconds

Step

not yet resolved

Measured in

human cells

Where in the cell

cytosol

Reaches people?

not tested in people

How settled

disputed: at least one study points the other way

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

← The whole pathway · This link as JSON