Pathway link GLN-RAG

Glutamine → Rag GTPases

Glutamine activates Rag GTPases.

Glutamine can switch on mTORC1 partly just by being burned for fuel: burning it makes a molecule that helps the Rag proteins pull mTORC1 to the lysosome.

Glutamine burned through glutaminolysis raises alpha-ketoglutarate, which promotes RagB GTP loading and mTORC1 translocation to the lysosome. This edge asserts the Rag-dependent route only.

The conditions it holds under

Cell-type dependent, and deliberately narrow: the separate claim that glutamine can reach mTORC1 without the Rags is carried by its own edge rather than folded in here.

Time it takes

minutes

Step

indirect (through steps not drawn here)

Measured in

human cells

Where in the cell

lysosome

Reaches people?

not tested in people

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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