{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "GLN-RAG",
  "claim": "Glutamine activates Rag GTPases",
  "source": {
   "name": "Glutamine",
   "entity": "glutamine"
  },
  "target": {
   "name": "Rag GTPases",
   "entity": "rag-gtpases"
  },
  "effect": "activates",
  "type": "signal-relay",
  "directness": "indirect",
  "timescale": "minutes",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "Glutamine burned through glutaminolysis raises alpha-ketoglutarate, which promotes RagB GTP loading and mTORC1 translocation to the lysosome. This edge asserts the Rag-dependent route only.",
  "mechanism_beginner": "Glutamine can switch on mTORC1 partly just by being burned for fuel: burning it makes a molecule that helps the Rag proteins pull mTORC1 to the lysosome.",
  "context": null,
  "boundary": "Cell-type dependent, and deliberately narrow: the separate claim that glutamine can reach mTORC1 without the Rags is carried by its own edge rather than folded in here.",
  "note": "Split from the Rag-independent claim on 2026-09-13 after external review: one edge was asserting a Rag-dependent mechanism and describing a Rag-independent one in the same sentence. 2026-10-10: this edge's curation status (Contested) and its field consensus (emerging) deliberately differ, and the evidence-audit page now labels the two dimensions separately instead of presenting either count as the number of disputed claims.",
  "consensus_contested": false,
  "curation_contested": true,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "DUR2012"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Contested",
  "url": "https://mtor-atlas.org/relation/GLN-RAG/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/GLN-RAG.json"
 }
}