Pathway link GLN-MTORC1-ARF1

Glutamine → mTORC1

Glutamine activates mTORC1.

Some experiments say glutamine has a second way in that skips the Rag proteins entirely. If that is right, the lysosome story is not the whole story – which is a big claim resting on thin evidence.

A second and contested way in: JEW2015 reports that glutamine activates mTORC1 without the Rag GTPases, through Arf1, and that leucine and glutamine therefore do not share one entry point. If it holds, Rag-dependent lysosomal recruitment is not the only route to the kinase.

The conditions it holds under

Cell-type dependent and not uniformly reproduced across labs. The Rag-dependent route is the separate GLN-RAG edge; neither edge should be read as covering the other.

Time it takes

minutes

Step

not yet resolved

Measured in

mammalian cells

Where in the cell

cytosol

Reaches people?

not tested in people

How settled

disputed: at least one study points the other way

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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