{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "GLN-MTORC1-ARF1",
  "claim": "Glutamine activates mTORC1",
  "source": {
   "name": "Glutamine",
   "entity": "glutamine"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "activates",
  "type": "signal-relay",
  "directness": "unresolved",
  "timescale": "minutes",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "A second and contested way in: JEW2015 reports that glutamine activates mTORC1 without the Rag GTPases, through Arf1, and that leucine and glutamine therefore do not share one entry point. If it holds, Rag-dependent lysosomal recruitment is not the only route to the kinase.",
  "mechanism_beginner": "Some experiments say glutamine has a second way in that skips the Rag proteins entirely. If that is right, the lysosome story is not the whole story – which is a big claim resting on thin evidence.",
  "context": null,
  "boundary": "Cell-type dependent and not uniformly reproduced across labs. The Rag-dependent route is the separate GLN-RAG edge; neither edge should be read as covering the other.",
  "note": null,
  "consensus_contested": true,
  "curation_contested": true,
  "contested": true,
  "confidence": {
   "mechanistic": "low",
   "human_relevance": "untested",
   "consensus": "contested"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "JEW2015"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Contested",
  "url": "https://mtor-atlas.org/relation/GLN-MTORC1-ARF1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/GLN-MTORC1-ARF1.json"
 }
}