Oliver's mTOR Atlas Evidence Platform
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Pathway link AKT-PRAS40

Akt/PKB PRAS40

Akt/PKB inhibits PRAS40.

Akt tags PRAS40, which then gets pulled away from mTORC1 – a second way insulin releases a brake.

Akt phosphorylates PRAS40, which then gets sequestered away from mTORC1 - a second, parallel way insulin lifts a brake.

The conditions it holds under

Three 2007 studies in cultured mammalian cells. Not tested in whole animals or in people, and how much this branch adds beside Akt's route through TSC2 is not measured.

Time it takes
seconds
Step
direct (one molecule acts on the other)
Measured in
mammalian cells
Where in the cell
cytosol
Reaches people?
plausible in people, not shown directly
How settled
settled in the literature

Studies behind it

YearEvidenceStudy
2007 M PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinaseSAN2007 Identified PRAS40 as the missing insulin-controlled brake INSIDE mTORC1. When insulin is absent PRAS40 clamps the complex shut; insulin makes Akt phosphorylate PRAS40, releasing the brake so Rheb can fully switch mTORC1 on. Explained how hormone signals set the exact strength of mTORC1 activity.
2007 M Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40VAN2007 Insulin signals to mTORC1 through Akt phosphorylation of the inhibitor PRAS40.
2007 M The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1OSH2007 PRAS40 is a physiological raptor-bound substrate and inhibitor of mTORC1.

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by
No researcher outside the project has checked this link yet.
Curator sign-off
Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
Curated by
Oliver Barton, with AI help for drafting; see how links are checked.

“Inhibits” describes the effect on the target's activity, not on how much of it there is.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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