Yifei Wang
Environmental toxicologist who contributed to a study of how early-life exposure to food-contact microplastics and a common plasticiser disrupts brain development through mTOR signalling
Environmental toxicology researcher · Central China Normal University, Wuhan
Exposed young mice showed autism-relevant behavioral changes alongside neuronal damage in the prefrontal cortex and reduced expression of two autism-risk genes. Proteomic screening pointed to the mTOR pathway as the central mechanism: exposure over-activated mTOR signaling, impairing autophagy and disrupting synapse-plasticity genes. Treating mice with rapamycin restored autophagy and ameliorated the behavioral changes.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Early-life exposure to polypropylene microplastics and DEHP induces ASD-relevant neurodevelopmental alterations involving mTOR-regulated autophagy impairment YANG2026 Co-author on a toxicology study in young mice showing combined exposure to polypropylene microplastics and DEHP produces autism-relevant behavioral changes via mTOR pathway overactivation and impaired autophagy — ameliorated by the mTOR inhibitor rapamycin. |
Co-authors in the Atlas 4
People with a profile here who share at least one study with Yifei Wang.
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- Ge Yang Researcher in Rui Li's group at Central China Normal University who has led mouse studies on how microplastics, nanoplastics and the plasticiser DEHP affect the young brain
- Ling Zhang Contributed to a 2026 toxicology study linking early-life exposure to microplastics and the plasticiser DEHP to autism-relevant brain changes through impaired mTOR-regulated autophagy
- Rui Li Toxicologist at Central China Normal University in Wuhan who leads mouse studies of how early-life exposure to microplastics, nanoplastics and plastic additives harms the developing brain
- Xiaojie Sun Contributed to a 2026 toxicology study linking early-life exposure to microplastics and the plasticiser DEHP to autism-relevant brain changes through impaired mTOR-regulated autophagy
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