Yifei Wang
Environmental toxicologist who contributed to a study of how early-life exposure to food-contact microplastics and a common plasticiser disrupts brain development through mTOR signalling
Environmental toxicology researcher · Central China Normal University, Wuhan
Exposed young mice showed autism-relevant behavioral changes alongside neuronal damage in the prefrontal cortex and reduced expression of two autism-risk genes. Proteomic screening pointed to the mTOR pathway as the central mechanism: exposure over-activated mTOR signaling, impairing autophagy and disrupting synapse-plasticity genes. Treating mice with rapamycin restored autophagy and ameliorated the behavioral changes.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Early-life exposure to polypropylene microplastics and DEHP induces ASD-relevant neurodevelopmental alterations involving mTOR-regulated autophagy impairment YANG2026 Co-author on a toxicology study in young mice showing combined exposure to polypropylene microplastics and DEHP produces autism-relevant behavioral changes via mTOR pathway overactivation and impaired autophagy — ameliorated by the mTOR inhibitor rapamycin. |
Co-authors in the Atlas
People with a profile here who share at least one study with Yifei Wang.
- Ling Zhang Contributed to a 2026 toxicology study linking early-life exposure to microplastics and the plasticiser DEHP to autism-relevant brain changes through impaired mTOR-regulated autophagy
- Xiaojie Sun Contributed to a 2026 toxicology study linking early-life exposure to microplastics and the plasticiser DEHP to autism-relevant brain changes through impaired mTOR-regulated autophagy