Valter D. Longo
Studies how nutrient-sensing pathways (including TOR and GH/IGF-1) and diet shape ageing and resistance to stress and disease, from yeast to mice and people.
University of Southern California · Professor of Gerontology and Biological Sciences; Director, USC Longevity Institute · PhD UCLA (1997)
Portrait: University of Southern California
Valter Longo is a professor at the University of Southern California and directs the USC Longevity Institute. According to his USC profile, he studied at the University of North Texas (BS, 1992), earned his PhD at UCLA (1997) and did postdoctoral training at USC (2000). His lab works on how ageing is regulated in yeast and in mammals, and how cells resist stress.
The Atlas includes the 2010 Science review he wrote with Luigi Fontana and Linda Partridge, 'Extending healthy life span: from yeast to humans'. It brings together evidence that eating less, or turning down nutrient-sensing signals such as mTOR and growth hormone/IGF-1, lets yeast, worms, flies and rodents live longer and stay healthier for longer.
The review is careful about people. Dietary restriction and lower nutrient-sensing activity are linked to protection from diabetes, cancer and heart disease in monkeys and humans, but direct proof that they slow ageing in humans is limited. This is why the review also discusses possible side effects.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2010 | R | Extending healthy life span--from yeast to humans FON2010 Review proposing that dietary restriction and reduced nutrient-sensing signalling (mTOR, GH/IGF-1) may slow ageing through shared, evolutionarily conserved mechanisms, with Longo as senior author. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Valter D. Longo.
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- Linda Partridge Showed that rapamycin extends fruit-fly lifespan through TORC1, via autophagy and reduced protein synthesis, and that it adds benefit even on top of dietary restriction
- Luigi Fontana Studies how diet and calorie restriction affect human ageing and metabolic health, and co-wrote a widely cited Science review linking dietary restriction to nutrient-sensing pathways such as mTOR
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