Tomohide Kinoshita
First author identifying how TCR-driven mTORC1 signaling epigenetically locks in Foxp3 expression in regulatory T cells
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Tomohide Kinoshita works in Shohei Hori's Laboratory of Immunology and Microbiology at the University of Tokyo's Graduate School of Pharmaceutical Sciences.
First author of a 2026 PNAS study showing that strong, sustained T-cell receptor signaling activates mTORC1 to boost translation of the TET2 (and likely TET3) DNA-demethylation enzymes, epigenetically locking in stable Foxp3 expression during regulatory T cell differentiation — revealing an unrecognized role for mTORC1 in immune tolerance.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | TCR-mTORC1 signaling promotes epigenetic stabilization of Foxp3 expression in regulatory T cells via TET protein translation KIN2026 First author: shows TCR-mTORC1 signaling stabilizes Foxp3 expression in regulatory T cells by boosting TET2/TET3 translation and TSDR demethylation. |
Co-authors in the Atlas
People with a profile here who share at least one study with Tomohide Kinoshita.
- Shohei Hori Senior author; laboratory head studying regulatory T cell differentiation and immune tolerance