Stefania Battaglioni
Cell biologist in Michael Hall's group at the Biozentrum Basel, first author of a 2022 Cell review that catalogued the direct substrates of mTOR
Biozentrum, University of Basel, Michael N. Hall group (PubMed affiliation 2020–2024) · Institute of Biochemistry, ETH Zurich (PubMed affiliation 2020)
mTOR is a kinase, an enzyme that switches other proteins on or off by attaching phosphate groups to them. Which proteins it acts on decides what mTOR does in the cell. Stefania Battaglioni is first author of the 2022 Cell review in this Atlas (BAT2022), written with Michael Hall, which gathered the known direct substrates of mTOR and explained how the two complexes, mTORC1 and mTORC2, end up acting on different targets. It is a reference map for anyone trying to trace a signal from mTOR to an effect.
Battaglioni's own lab work in the Hall group looks for new mTOR substrates. A 2024 PNAS paper, with Battaglioni as first author, showed that mTORC1 phosphorylates and stabilises a protein called LST2, which in turn holds back the EGF receptor, a growth-factor receptor. A 2023 EMBO Journal study, on which Battaglioni is a co-author, found that yeast TORC1 switches off Stm1, a factor that keeps ribosomes dormant, so that protein synthesis can restart when nutrients return.
Battaglioni also contributed to a 2020 Nature Metabolism study, led from ETH Zurich, showing that the pH inside cells helps drive cell division and tumour growth by raising cyclin D1. PubMed lists Battaglioni at the Biozentrum of the University of Basel through 2024. A current job title could not be confirmed.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2022 | R | mTOR substrate phosphorylation in growth control BAT2022 First author: wrote, with Michael Hall, the Cell review that catalogues direct mTOR substrates and how mTORC1 and mTORC2 choose their targets. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Stefania Battaglioni.
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- Michael N. Hall Discovered TOR in yeast in 1991 and established it as a central controller of cell growth that responds to nutrients. His lab later showed that TOR works in two distinct complexes, TORC1 and TORC2, only one of which is blocked by rapamycin
- Timm Maier Solved some of the first cryo-EM structures of human mTORC1 (with Nenad Ban's group) and mTORC2, including a high-resolution map of mTORC2
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