Pan Zheng
Showed as senior author that blood stem cells need TSC to keep mTOR in check in order to stay dormant, and that rapamycin restores the function of aged blood stem cells in mice
Co-founder & CMO, OncoC4, Inc. · Professor, Univ. of Michigan, Ohio State, Children's National, Univ. of Maryland IHV · PhD, Yale · MD, Peking Union Medical College
OncoC4, Inc. (Rockville, Maryland, USA) ↗ ORCID0000-0003-2598-3544 ↗
Portrait: OncoC4, Inc.
Senior author on both CHE2008 and CHE2009 (HSC aging/mTOR). Long partnership with immunologist Yang Liu spanning Yale, Ohio State, Michigan, Children's National, Univ. of Maryland IHV; co-discovered the CD24–Siglec-10 checkpoint, translated into CD24Fc (tested for GVHD and severe COVID).
Co-founded OncoC4 (formerly OncoImmune), where she is now CMO directing global checkpoint-immunotherapy trials.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2008 | A | TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species CHE2008 Senior author: TSC-mTOR keeps blood stem cells quiescent by repressing mitochondrial ROS. |
| 2009 | A | mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells CHE2009 Senior author: mTOR hyperactivation drives HSC aging; rapamycin restores function and immune competence. |
Co-authors in the Atlas 3
People with a profile here who share at least one study with Pan Zheng.
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- Chong Chen 2 shared studies Showed that blood stem cells need TSC to keep mTOR in check in order to stay dormant and self-renew, and that rapamycin restores the function of aged blood stem cells in mice
- Kun-Liang Guan Showed how growth-factor and energy signals reach mTORC1 through TSC2 and Rheb, and, in parallel with the Sabatini lab, that the Rag GTPases carry the amino-acid signal. His lab also found that AMPK and mTORC1 control autophagy by phosphorylating the kinase ULK1 at different sites
- Yu Liu Cancer biologist working on how tumour-suppressor loss and epigenetic state decide whether a cell stays differentiated
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