Chong Chen
Showed that blood stem cells need TSC to keep mTOR in check in order to stay dormant and self-renew, and that rapamycin restores the function of aged blood stem cells in mice
Professor, West China Hospital, Sichuan University · postdoc, Scott Lowe lab, Cold Spring Harbor Laboratory & MSKCC · PhD, University of Michigan
The Chen-Liu Lab, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University (Chengdu, Sichuan, China) ↗ Lab lineagetrained under Scott W. Lowe →
Portrait: West China Hospital, Sichuan University
First author (CHE2008): deleting Tsc1 (unleashing mTOR) drove resting blood stem cells into rapid division, flooded them with ROS, destroyed regenerative capacity — antioxidant partly rescued them. Follow-up (CHE2009): mTOR rises naturally in aged HSCs, and rapamycin restores regenerative capacity and vaccine response.
Postdoc'd with Scott Lowe (lineage plasticity/therapy resistance), now co-runs a lab with Yu (Kiki) Liu (co-author on both original papers) studying epigenetic reprogramming in cancer.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2008 | A | TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species CHE2008 Deleting Tsc1 drives blood stem cells into rapid division, ROS flood, and exhausts self-renewal. |
| 2009 | A | mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells CHE2009 mTOR rises in aged HSCs; rapamycin restores their regenerative function and vaccine response. |
Co-authors in the Atlas 3
People with a profile here who share at least one study with Chong Chen.
ShowHide
- Pan Zheng 2 shared studies Showed as senior author that blood stem cells need TSC to keep mTOR in check in order to stay dormant, and that rapamycin restores the function of aged blood stem cells in mice
- Kun-Liang Guan Showed how growth-factor and energy signals reach mTORC1 through TSC2 and Rheb, and, in parallel with the Sabatini lab, that the Rag GTPases carry the amino-acid signal. His lab also found that AMPK and mTORC1 control autophagy by phosphorylating the kinase ULK1 at different sites
- Yu Liu Cancer biologist working on how tumour-suppressor loss and epigenetic state decide whether a cell stays differentiated
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.