Meijie Li
Dartmouth researcher, working with the Luikart and Hong labs, studying how PTEN controls the neuronal microtubule cytoskeleton through mTORC2 rather than mTORC1
Department of Molecular and Systems Biology · Geisel School of Medicine at Dartmouth College · Hanover, NH, USA
Meijie Li works at Dartmouth's Geisel School of Medicine with Bryan Luikart (now at the University of Alabama at Birmingham) and Jennifer Hong studying how the tumor-suppressor PTEN shapes neuronal growth. The study behind this entry showed that PTEN loss accelerates microtubule polymerization in peripheral sensory neurons specifically via mTORC2 — not mTORC1 — and only at the axon's growth cone, pointing to the growth-cone microtubule cytoskeleton as a potential target for nerve-regeneration therapies.
PubMed shows Li as a co-author on an earlier (2022) paper from the same group on PTEN and dendritic arborization via microtubule polymerization, indicating a multi-year role in this research line.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | PTEN regulates microtubule polymerization via mTORC2, but not mTORC1, in peripheral sensory neurons EVA2026 Co-author on the Dartmouth study showing that PTEN loss accelerates microtubule polymerization in peripheral sensory neuron growth cones through mTORC2, not mTORC1. |