Matthew Meyerson
Cancer geneticist whose group has helped identify key genes mutated in lung cancer, and who contributed the cancer-genome analysis to the discovery that GATOR1 is a tumour suppressor acting on mTORC1
Charles A. Dana Chair in Human Cancer Genetics · Professor of Genetics and Medicine, Harvard Medical School · Director, Center for Cancer Genomics, Dana-Farber Cancer Institute · Member, Broad Institute
Portrait: Dana-Farber Cancer Institute
BAR2013 is a Science paper from David Sabatini's group that found GATOR, a protein assembly that talks to the Rag GTPases which tell mTORC1 whether amino acids are available. One part, GATOR1, switches the Rags off when amino acids run low. Its genes are mutated in human cancers, and cells with such mutations keep mTORC1 active even without amino acids and are unusually sensitive to rapamycin. Meyerson is the second to last author.
Meyerson is a professor of genetics and medicine at Harvard Medical School, holds the Charles A. Dana Chair in Human Cancer Genetics, and directs the Center for Cancer Genomics at Dana-Farber Cancer Institute, with membership at the Broad Institute. His group, which he started at Dana-Farber in 1998, uses genomic and genetic methods to find the causes of cancer, with a focus on lung cancer.
His honours include election to the National Academy of Medicine (2018), the Alfred G. Knudson Award in Cancer Genetics (2019) and the Paul Marks Prize in Cancer Research (2009).
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2013 | M | A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 BAR2013 Senior co-author of the Science paper identifying GATOR1 as a tumour suppressor complex that switches off Rag GTPase signalling to mTORC1. |
Co-authors in the Atlas 5
People with a profile here who share at least one study with Matthew Meyerson.
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- Brian C. Grabiner Catalogued cancer-associated MTOR mutations and showed that many of them hyperactivate the kinase and can predict sensitivity to rapamycin; he also contributed to the discovery of GATOR1
- David M. Sabatini Identified mTOR (as RAFT1) in 1994. His lab then mapped much of the machinery around it: raptor and rictor at the core of mTORC1 and mTORC2, the Rag–Ragulator system that docks mTORC1 on the lysosome, and the sensors that detect leucine, arginine and SAM
- Kathleen Ottina Researcher in David Sabatini's lab at the Whitehead Institute and HHMI at MIT who contributed to studies of the GATOR1 amino acid off-switch, mTORC1 feedback on growth-factor signalling, and cancer drug resistance
- Liron Bar-Peled Showed as a Sabatini-lab graduate student that Ragulator switches the Rag GTPases on, acting as their GEF. He also discovered GATOR1 and GATOR2; GATOR1 switches the Rags off and its genes are mutated in some cancers
- Lynne Chantranupong Showed as a Sabatini-lab graduate student that the Sestrins act through GATOR2 to regulate amino-acid signalling to mTORC1. She then discovered the CASTOR proteins, the cell's arginine sensors for the pathway
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