Loren Kell
First author identifying a direct genoprotective effect of rapamycin against DNA damage in ageing human immune cells
DPhil student, Department of Biochemistry, Oriel College, University of Oxford · Mellon Scholar in Ageing and Cell Senescence · BA, University College London
Cox Lab of Ageing and Cell Senescence, University of Oxford (Oxford, England, United Kingdom) ↗ ORCID0000-0003-1322-2027 ↗
Loren Kell grew up in North Wales and read for a BA at University College London before moving to Oxford for postgraduate work. She is now a DPhil student in the Department of Biochemistry at Oriel College, working in Lynne Cox's laboratory on ageing and cell senescence as the college's Mellon Scholar in the field.
Her research asks how the immune system changes with time, and specifically whether mTOR inhibition can rejuvenate senescent immune cells — work that extends into clinical trials examining immune-system changes in older adults given mTOR inhibitors.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | H | Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage KEL2026 First author: shows rapamycin protects ageing human T cells from DNA damage directly, independent of protein synthesis, cell-cycle arrest or autophagy, and reduces a senescence marker (p21) in a placebo-controlled human trial of low-dose rapamycin. |
Co-authors in the Atlas
People with a profile here who share at least one study with Loren Kell.
- Ghada Alsaleh Senior author studying autophagy and immune-cell ageing; identified a genoprotective mechanism for rapamycin