Ghada Alsaleh
Senior author studying autophagy and immune-cell ageing; identified a genoprotective mechanism for rapamycin
Associate Professor & Versus Arthritis Career Development Fellow, Kennedy Institute of Rheumatology, University of Oxford · Official Fellow, Reuben College · PharmD & PhD, University of Strasbourg
Alsaleh Group, Kennedy Institute of Rheumatology, University of Oxford (Oxford, England, United Kingdom) ↗ ORCID0000-0002-4211-3420 ↗
Ghada Alsaleh trained as a pharmacist before completing a PharmD and PhD at the University of Strasbourg. She joined Katja Simon's group at Oxford in 2017 as a postdoctoral researcher working on autophagy in ageing immune cells, and now leads her own group at the Kennedy Institute of Rheumatology as a Versus Arthritis Career Development Fellow and Associate Professor.
Her lab studies how declining autophagy and lysosomal function — including falling TFEB activity — drive immune-cell dysfunction with age, with translational programmes spanning osteoarthritis and, through the UK's first Space Innovation Lab at the Botnar Institute, the effects of microgravity on ageing.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | H | Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage KEL2026 Senior author: identifies a previously unrecognised 'genoprotective' mechanism for rapamycin — direct protection of ageing human immune cells against DNA damage — including a placebo-controlled human trial showing reduced p21 (a senescence marker) with low-dose rapamycin. |
Co-authors in the Atlas
People with a profile here who share at least one study with Ghada Alsaleh.
- Loren Kell First author identifying a direct genoprotective effect of rapamycin against DNA damage in ageing human immune cells