Long He
Research faculty member in John Blenis's lab at Weill Cornell who studies how mTORC1 controls cell metabolism, and first author of the lab's 2025 review of mTORC1 as a conductor of metabolism and growth
Assistant Professor of Research in Pharmacology · Weill Cornell Medicine (Blenis Lab) – PhD, Chungnam National Univ., 2011
Blenis Lab, Dept. of Pharmacology & Meyer Cancer Center, Weill Cornell Medicine (New York, New York, USA) ↗ ORCID0000-0003-4721-9221 ↗
Long He has been a long-standing member of John Blenis's laboratory — one of the labs that, alongside David Sabatini's, defined much of modern mTOR signaling — first at Harvard and since its move to Weill Cornell Medicine, where he now holds the title Assistant Professor of Research in Pharmacology.
His publication record traces the Blenis lab's core scientific arc on how mTORC1 rewires metabolism: lipogenic splicing via S6K1-SRPK2 (2017), Foxk1-mediated metabolic reprogramming (2018), m6A-dependent mRNA degradation (2021), FAM120A coupling SREBP transcription to lipogenic splicing (2023), and direct sensing of dietary linoleic acid via FABP5-mTORC1 signaling (2025).
That work culminated in the paper flagged here: 'mTORC1, the maestro of cell metabolism and growth' (Genes & Development, 2025), where he is listed first and shares the corresponding-author line with Blenis.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2025 | R | mTORC1, the maestro of cell metabolism and growth HE2025 First and co-corresponding author (with John Blenis) of this comprehensive review of mTORC1's role in metabolic rewiring, disease, and drug targeting. |
Co-authors in the Atlas
People with a profile here who share at least one study with Long He.
- John Blenis Showed early on that rapamycin blocks S6 kinase, then worked out how mTORC1 drives cell growth through its two main translation targets, S6K1 and 4E-BP1. His lab also found, in parallel with the Sabatini lab, that mTORC1 phosphorylates Grb10, a feedback brake on insulin signalling