Liyun Shi
Immunologist at Zhejiang Shuren University in Hangzhou whose group showed in mice that losing the lysosomal mTOR-activating protein Lamtor5 with age pushes macrophages into senescence and spreads inflammation
Key Laboratory of Artificial Organs and Computational Medicine, Institute of Translational Medicine, Zhejiang Shuren University (papers 2024–2026)
Liyun Shi is senior author of an Atlas study (LV2026) on why the immune system ages. Lamtor5 is one of the five small proteins of the Ragulator complex, the platform on the lysosome surface where mTORC1, the growth-control complex, is switched on. The team found that Lamtor5 levels fall with age in mouse macrophages, the immune cells that clean up debris and fight infection. Without enough Lamtor5 the macrophages became senescent, a state in which cells stop dividing but release inflammatory signals. The study traced this to the cGAS-STING pathway, an alarm system that senses DNA in the wrong place in the cell, and showed that the inflammation spread to other tissues. Restoring Lamtor5 in old mice reduced these signs of immune ageing.
The finding links a component of the mTOR machinery to inflammaging, the low-level chronic inflammation of old age. It is a mouse study, so whether Lamtor5 behaves the same way in human immune cells remains open.
PubMed lists Shi at the Institute of Translational Medicine of Zhejiang Shuren University in Hangzhou on the Atlas paper and on a 2024 study, with clinical partners, of how gut bacteria and a population of macrophages drive bowel inflammation in children with glycogen storage disease type Ib. No official profile page was found, so the exact current title is not confirmed.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation. LV2026 Senior author: led the mouse study showing that age-related loss of Lamtor5 drives macrophage senescence and cGAS-STING inflammation, reversed by restoring Lamtor5. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Liyun Shi.
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- Nianyin Lv Researcher at Nanjing University of Chinese Medicine who led a mouse study showing that the age-related loss of Lamtor5, a part of the lysosomal platform that helps switch on mTORC1, drives immune ageing through inflammation
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