Laura S. Harrington
First author of the 2004 study showing that TSC1-2 loss blunts insulin signalling through S6K1-driven feedback on IRS proteins
Institute of Cancer Research, London (2004)
Laura Harrington did this work in Richard Lamb's laboratory at the Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, London, the affiliation PubMed gives for the study. The Atlas has no other sourced details of her career, so this profile covers only that paper.
In the Atlas she is first author of HAR2004 in the Journal of Cell Biology. Cells without TSC1-2 keep S6K1 switched on, and S6K1 then shuts down IRS-1, both by lowering its gene expression and by phosphorylating it directly. The result is a weak insulin-PI3K response. The authors suggested this may explain why tumours caused by TSC loss rarely become malignant.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2004 | M | The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins HAR2004 First author: TSC1-2 loss keeps S6K1 active, which represses and phosphorylates IRS-1 and blunts insulin-PI3K signalling (cells). |
Co-authors in the Atlas
People with a profile here who share at least one study with Laura S. Harrington.
- Greg M. Findlay Uses pluripotent stem cells to study how faulty signalling by protein kinases causes intellectual disability
- Richard F. Lamb Studied how amino acids and growth signals reach mTOR, including the IRS feedback loop and nutrient signalling through MAP4K3
Every researcher with a profile →
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