Greg M. Findlay
Uses pluripotent stem cells to study how faulty signalling by protein kinases causes intellectual disability
Principal Investigator, MRC PPU · Senior Lecturer · University of Dundee · Sir Henry Dale Fellow
MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee (Dundee, UK) ↗ Lab lineagetrained under Richard F. Lamb →
Portrait: MRC PPU, University of Dundee
Greg Findlay is a Principal Investigator at the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee. His group, set up in 2014, uses pluripotent stem cells to study understudied protein kinases and to learn how faulty signalling causes intellectual disability. He is a Wellcome Trust/Royal Society Sir Henry Dale Fellow.
He studied biochemistry at Dundee and did his PhD at the Institute of Cancer Research in London with Richard Lamb, looking for new parts of the mTOR pathway. He then worked as a postdoc with Tony Pawson in Toronto on protein complexes in stem cells.
In the Atlas he is a co-author of HAR2004 from his PhD lab. That study showed that when TSC1-2 is lost, S6K1 stays active and shuts down IRS-1, cutting the cell's response to insulin. This is one of the papers that placed mTORC1's main negative feedback loop.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2004 | M | The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins HAR2004 Co-author: loss of TSC1-2 keeps S6K1 active, which suppresses IRS-1 and blunts insulin-PI3K signalling (cells). |
Co-authors in the Atlas
People with a profile here who share at least one study with Greg M. Findlay.
- Laura S. Harrington First author of the 2004 study showing that TSC1-2 loss blunts insulin signalling through S6K1-driven feedback on IRS proteins
- Richard F. Lamb Studied how amino acids and growth signals reach mTOR, including the IRS feedback loop and nutrient signalling through MAP4K3
Every researcher with a profile →
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