José A. Martina
Cell biologist in Rosa Puertollano's group at the NHLBI who works on how mTORC1 and the Rag GTPases control the lysosomal transcription factors TFEB and TFE3.
Researcher, Rosa Puertollano's group, Cell and Developmental Biology Center (formerly Laboratory of Cell Biology), NHLBI, National Institutes of Health, Bethesda
José Martina was first author of the 2013 Journal of Cell Biology study with Rosa Puertollano (MAR2013). In human cells, TFEB reached the lysosome by binding active Rag GTPase heterodimers through its first 30 amino acids, and this recruitment was needed for mTORC1 to phosphorylate TFEB at S211. Depleting the Rags or the Ragulator subunit p18 abolished lysosomal TFEB, and some MITF isoforms behaved the same way.
Martina has worked with Puertollano at the NHLBI for many years on TFEB and TFE3, including a 2025 EMBO Reports study on two TFE3 isoforms that share the same Rag/mTORC1 control.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2013 | M | Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes MAR2013 First author: active Rag GTPases recruit TFEB and MITF to lysosomes, where mTORC1 phosphorylates and inhibits TFEB. |
Co-authors in the Atlas
People with a profile here who share at least one study with José A. Martina.
- Rosa Puertollano Studies how lysosomes are regulated, including how mTORC1 controls the transcription factors TFEB and TFE3 that switch on autophagy and lysosome genes.
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