John B. Hogenesch
Circadian-rhythm geneticist who uses genome-wide methods to map which genes the body clock controls in each tissue.
Thomas F. Boat Chair, Cincinnati Children's Hospital Medical Center · Appointments in Human Genetics, Pulmonary Medicine and Immunobiology
Portrait: Cincinnati Children's Hospital Medical Center
John Hogenesch studies the body clock, the roughly 24-hour timer that tells cells when to be active and when to rest. His laboratory is known for large genomic surveys that ask which genes switch on and off with the clock in different organs, and for building tools that other chronobiologists use to detect rhythms in data.
In the 2018 PLoS Genetics paper in the Atlas, led by Andrew Liu's group, he is a co-author on work showing that mTOR sets how the clock runs. Blocking mTOR made the clock tick more slowly and with a weaker swing, while activating mTOR made it faster and stronger, in both brain and peripheral tissues.
Hogenesch now holds the Thomas F. Boat Chair at Cincinnati Children's Hospital Medical Center, where his lab moved to work on circadian medicine.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2018 | A | mTOR signaling regulates central and peripheral circadian clock function RAM2018 Co-author of the study showing that mTOR signalling controls the period and amplitude of the central and peripheral circadian clocks. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with John B. Hogenesch.
ShowHide
- Andrew C. Liu Circadian biologist who studies how the body clock works at the molecular level and how it connects with metabolism and signalling pathways such as mTOR.
- Chidambaram Ramanathan Circadian biologist at the University of Memphis who showed that mTOR signalling sets the speed and strength of the body's daily clocks
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.