Andrew C. Liu
Circadian biologist who studies how the body clock works at the molecular level and how it connects with metabolism and signalling pathways such as mTOR.
Professor, Department of Physiology and Aging, University of Florida (since 2018) · University of Memphis (Assistant and Associate Professor, 2008–2017)
Liu Lab, Department of Physiology and Aging, College of Medicine, University of Florida (Gainesville, Florida, USA) ↗ ORCID0000-0003-1927-0900 ↗
Portrait: UF Health
Andrew Liu studies the circadian clock, the roughly 24 hour timer that runs inside nearly every cell. He earned a PhD in biochemistry at the University of Michigan, did postdoctoral training at The Scripps Research Institute, and has worked on mammalian clocks since 2003.
He ran a lab at the University of Memphis from 2008 to 2017 and joined the University of Florida in 2018.
The study in this Atlas asked whether mTOR affects the clock. Lowering mTOR activity made the clock run slower and with a weaker swing, and raising it made the clock run faster with a stronger swing. This was seen in cells, in brain and liver tissue and in mice with less mTOR, so nutrient signalling and daily timing are tied together.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2018 | A | mTOR signaling regulates central and peripheral circadian clock function RAM2018 Showed that mTOR activity sets the speed and strength of the circadian clock in cells, brain (SCN) and liver clocks, and in mTOR heterozygous mice; Liu is the senior author. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Andrew C. Liu.
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- Chidambaram Ramanathan Circadian biologist at the University of Memphis who showed that mTOR signalling sets the speed and strength of the body's daily clocks
- John B. Hogenesch Circadian-rhythm geneticist who uses genome-wide methods to map which genes the body clock controls in each tissue.
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