Jie Wang
Corresponding author of a 2026 JACS paper identifying PKM2 as a direct methionine-sensing protein that signals into mTORC1 via GATOR2.
Associate Professor, Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis · SUSTech, China – PhD, Peking University (2020)
Wang Jie Lab, Department of Chemistry, Southern University of Science and Technology (SUSTech) (Shenzhen, China) ↗ ORCID0000-0001-7602-5050 ↗
Portrait: Southern University of Science and Technology (SUSTech), Wang Jie Lab People page
Jie Wang is an associate professor of chemistry at SUSTech, where he runs a lab on bioorthogonal chemistry, genetic code expansion, and enzyme engineering, after training with Aiwen Lei at Wuhan University and Peng Chen/Chu Wang at Peking University.
As corresponding author on a 2026 JACS paper, his team designed a 'Trojan' photoaffinity methionine probe to fish out proteins that directly sense methionine in living cells. They found PKM2 — better known as a glycolytic enzyme — moonlights as a methionine sensor, binding methionine through a newly discovered pocket and relaying that signal through GATOR2 to control mTORC1. This adds a direct methionine sensor to mTOR's nutrient-sensing machinery, alongside the previously discovered SAMTOR, which senses the methionine metabolite SAM rather than methionine itself.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | "Trojan" Methionine Probe Reveals PKM2 as a Methionine-Sensing Protein in the mTORC1 Pathway SANG2026 Corresponding author showing PKM2 acts as a novel direct methionine sensor that signals through GATOR2 into mTORC1, complementing the known SAMTOR sensing pathway. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Jie Wang.
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- Jiaqi Zhao Co-author; chemical biologist who helped build a chemical probe revealing a glycolytic enzyme's secret second job as a methionine sensor for mTORC1.
- Zixin Sang Chemical biologist at SUSTech in Shenzhen who used a light-activated methionine probe to identify PKM2 as a methionine sensor for mTORC1
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