Harold Jefferies
Biochemist who worked on S6 kinase and 5'TOP mRNA translation in George Thomas's lab and has studied the molecular machinery of autophagy in Sharon Tooze's lab since 2003.
Principal Laboratory Research Scientist, Tooze lab, The Francis Crick Institute (since 2003) · Peter Parker's lab, ICRF/Cancer Research UK (2000–2003) · Julian Downward's lab, ICRF (from 1997) · PhD with George Thomas (1994) and postdoc in Basel · BSc in biochemistry, Newcastle University
Molecular Cell Biology of Autophagy Laboratory (Tooze lab), The Francis Crick Institute (London, England, United Kingdom) ↗ Lab lineagetrained under George Thomas →
Harold Jefferies was first author of the 1997 EMBO Journal study from George Thomas's lab at the Friedrich Miescher Institute (JEF1997). Using reporter mRNAs and S6 kinase mutants in mammalian cells, the team concluded that rapamycin blocks the translation of 5'TOP mRNAs, which encode ribosomal proteins, by blocking p70 S6 kinase. Later knockout work found 5'TOP control that does not need S6K1, so this step is no longer the accepted model.
Jefferies did his PhD in George Thomas's lab on S6 phosphorylation, S6 kinase and translation, followed by postdoctoral work in Basel. He then moved to London, working on Ras, PI3K and Raf signalling in Julian Downward's lab and on PI3K and PKD drug-discovery projects in Peter Parker's lab, before joining Sharon Tooze's autophagy lab in 2003, now at the Francis Crick Institute.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 1997 | M | Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k JEF1997 First author: rapamycin suppresses 5'TOP mRNA translation in mammalian cells, which the authors traced to inhibition of p70 S6 kinase. |
Co-authors in the Atlas
People with a profile here who share at least one study with Harold Jefferies.
- George Thomas Purified and cloned S6K1, the kinase that became the classic readout of mTORC1 activity. His lab later showed that mice lacking S6K1 resist diet-induced obesity, and that amino acids signal to mTORC1 through the lipid kinase hVps34 (GUL2008)
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