Hangyul Song
Researcher in Chang-Myung Oh's lab at GIST who tested urolithin A, a gut-microbe product, in mice with a stiff-heart form of heart failure
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (papers with Chang-Myung Oh)
Hangyul Song is the first author of SONH2026, a study in Experimental and Molecular Medicine from Chang-Myung Oh's lab at the Gwangju Institute of Science and Technology (GIST) in South Korea. It deals with heart failure with preserved ejection fraction (HFpEF): the heart still pumps out a normal share of its blood with each beat, but the muscle is stiff and thick and fills poorly. HFpEF is common in older people with obesity and diabetes and has few good treatments.
Urolithin A is made by gut bacteria from compounds in foods such as pomegranates and walnuts. In mice with HFpEF it eased heart stiffness, thickening and scarring. In heart cells it switched on AMPK, the energy sensor, and lowered mTOR activity. That restored mitophagy, the clearing of damaged mitochondria. Urolithin A also changed the gut microbiome and lowered ceramides, fatty molecules that harm heart cells. The results come from mice and cell models, not from patients.
PubMed lists several papers shared by Song and Oh. No separate profile was found, so the position shown is the affiliation on the Atlas paper.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Urolithin A activates mitophagy via the AMPK-mTOR axis and modulates the gut-ceramide axis to ameliorate cardiac remodeling in HFpEF SONH2026 First author: showed in HFpEF mice that urolithin A restores mitophagy through AMPK activation and mTOR inhibition and lowers ceramides through the gut microbiome. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Hangyul Song.
ShowHide
- Chang-Myung Oh Metabolism researcher at GIST in South Korea whose lab studies heart and metabolic disease in mice, including how urolithin A protects the stiff heart in HFpEF
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.