Guozhong Lyu
Burn and wound-repair specialist in Wuxi whose group studies natural compounds, biomaterials and devices that improve healing and reduce scarring
Burn and Trauma Treatment Center, Affiliated Hospital of Jiangnan University · Engineering Research Center of the Ministry of Education for Wound Repair Technology, Jiangnan University · National Emergency Medical Research Center, Emergency General Hospital, Beijing
Hypertrophic scars are thick, raised scars that form after burns or surgery when skin fibroblasts make too much collagen. In a 2026 study in Frontiers in Pharmacology led by Guozhong Lyu as senior author, the plant compound dihydromyricetin lowered collagen and other scar markers in fibroblasts from human scars and flattened scars in a rabbit ear model. Activating tags on the growth-signalling proteins AKT and mTOR dropped at the same time, but the authors say this does not show that the compound acts through mTOR.
Lyu works at the Burn and Trauma Treatment Center of the Affiliated Hospital of Jiangnan University in Wuxi, at the university's Wuxi School of Medicine and its Ministry of Education engineering research centre for wound repair technology, and also lists the National Emergency Medical Research Center in Beijing. The group's recent papers range widely across wound healing: a compound from mangosteen that calms high-glucose inflammation in immune cells, a nanotube-based foam dressing for diabetic wounds in rats, and a flexible electromagnetic coil patch that speeds healing of skin wounds in rats (all 2026).
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Dihydromyricetin attenuates fibrosis-associated features of hypertrophic scar with accompanying changes in PI3K/AKT/mTOR-related signaling. CAO2026B Senior author of the dihydromyricetin study on hypertrophic scar fibroblasts and the rabbit ear scar model. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Guozhong Lyu.
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- Peng Cao Wound-repair researcher at the Burn and Trauma Treatment Center in Wuxi who tests natural compounds against scarring and diabetic wound inflammation
- Yunwei Wang Burn and wound-repair researcher who contributed to a study testing the plant flavonoid dihydromyricetin as an anti-scarring treatment
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