Fuyuhiko Tamanoi
Biochemist who studied protein farnesylation and the Rheb–TOR pathway in fission yeast and mammalian cells; senior author of the study that found activating mTOR mutations in human cancer data
Program-Specific Professor & PI, iCeMS, Kyoto University · Professor of Microbiology, Immunology & Molecular Genetics, UCLA (from 1997; on faculty since 1993) · University of Chicago (1985–1993) · Cold Spring Harbor Laboratory (1980–1985) · Postdoc, Harvard Medical School (1977–1980) · PhD, Nagoya University (1977)
Fuyuhiko Tamanoi is the senior author of SAT2010, done in his lab at UCLA with Tatsuhiro Sato as first author. The study showed that two point mutations in mTOR found in cancer genome databases, S2215Y and R2505P, keep mTOR signalling on even when cells are starved of nutrients, while leaving the mutants sensitive to rapamycin. His lab had earlier found activating mutations in the fission yeast TOR kinase Tor2 and in its upstream regulator Rheb, and carried that approach over to mTOR.
Tamanoi trained in biochemistry at Tokyo University and earned his PhD at Nagoya University (1977), followed by postdoctoral work at Harvard Medical School. He was a staff investigator at Cold Spring Harbor Laboratory and a faculty member at the University of Chicago before joining UCLA in 1993. His lab identified protein farnesyltransferase and geranylgeranyltransferases and worked on their inhibitors, and later developed mesoporous silica nanoparticles for drug delivery. He now leads a group at the Institute for Integrated Cell-Material Sciences at Kyoto University, working on nanoparticles and cancer therapy.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2010 | M | Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer SAT2010 Senior author: cancer-derived mTOR point mutations confer constitutive mTOR signalling under nutrient starvation. |
Co-authors in the Atlas
People with a profile here who share at least one study with Fuyuhiko Tamanoi.
- Tatsuhiro Sato First author of the study that found single amino-acid changes in mTOR, taken from cancer genome databases, that keep mTOR signalling on during nutrient starvation
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