Douglas R. Green
Cell death researcher known for work on apoptosis and the immune system, whose group also showed that the transcription factor Myc drives the metabolic switch of activated T cells.
Peter C. Doherty Endowed Chair of Immunology, St. Jude Children's Research Hospital · PhD, Yale University (1981) · Member, National Academy of Sciences (2020)
Green Lab, Department of Immunology, St. Jude Children's Research Hospital (Memphis, Tennessee, USA) ↗ ORCID0000-0002-7332-1417 ↗
Portrait: St. Jude Children's Research Hospital
Douglas Green is an immunologist at St. Jude Children's Research Hospital in Memphis. He is best known for studying apoptosis, the controlled way in which cells die, in cancer and in the immune system. His honours include election to the US National Academy of Sciences in 2020.
The study in the Atlas, led by Ruoning Wang in his laboratory, asked how T cells prepare for a fight. When a T cell is activated it must grow and divide fast, so it changes how it uses sugar and the amino acid glutamine. The team found that the transcription factor Myc, not HIF1 alpha, controls this switch, and that glutamine feeds the making of polyamines, small molecules cells need to grow.
The paper connects immune cell activation to nutrient use, the same theme in which mTOR acts as a master controller of growth. It is included in the Atlas because the metabolic reprogramming it describes is part of the picture of how mTOR-linked growth signals shape T cell responses.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2011 | A | The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation WAN2011 Senior author: Myc controls the glucose and glutamine metabolic reprogramming of activated T cells, linking glutaminolysis to polyamine synthesis. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Douglas R. Green.
ShowHide
- Hongbo Chi Showed that regulatory T cells need mTORC1 signalling to fuel their suppressive function, and studies how mTOR-driven metabolism steers T-cell fate
- Ruoning Wang Showed as first author, in Douglas Green's lab, that the transcription factor Myc drives the metabolic switch of activated T cells, and now leads an immunometabolism lab
Every researcher with a profile →
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.