Christine Mayer
First author of the 2004 Genes & Development study showing that mTOR activates TIF-IA to link rRNA synthesis to nutrients.
German Cancer Research Center (DKFZ), Heidelberg
Christine Mayer is first author of MAY2004. In HeLa cells, rapamycin almost abolished synthesis of the 45S pre-rRNA while the amounts of the Pol I machinery stayed the same, so mTOR acts on the activity of the factor TIF-IA. Rapamycin changed which sites of TIF-IA were phosphorylated and moved it out of the nucleus.
In PubMed she is listed in the Division of Molecular Biology of the Cell II at the German Cancer Research Center in Heidelberg.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2004 | M | mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability MAY2004 First author. mTOR switches on TIF-IA to drive ribosomal RNA transcription. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Christine Mayer.
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- Ingrid Grummt Last author of the 2004 Genes & Development study showing that mTOR activates TIF-IA to link rRNA synthesis to nutrients.
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