Cherie-Ann O. Nathan
Head and neck surgeon and cancer researcher who tests whether drugs such as the mTOR inhibitor everolimus can help patients whose tumours resist immunotherapy.
LSU Health Shreveport · Chair and Professor of Otolaryngology-Head and Neck Surgery · Feist-Weiller Cancer Center · Clinician-scientist
Portrait: LSU Health Shreveport
Cherie-Ann Nathan is a head and neck cancer surgeon and the chair of the Department of Otolaryngology-Head and Neck Surgery at LSU Health Shreveport. She also directs head and neck surgery and research there and works with the Feist-Weiller Cancer Center.
Her 2026 study in the Atlas looked at head and neck squamous cell carcinoma with a mutated TP53 gene. These tumours often stay 'immune-cold', meaning immune cells do not enter them, and they respond poorly to immunotherapy. In mouse models, the mTOR inhibitor everolimus slowed tumour growth.
The treatment brought more CD8+ T cells and dendritic cells into the tumour, reduced regulatory T cells and lowered PD-1 and PD-L1 levels. The authors suggest mTOR inhibition could be a way to prepare such tumours for immunotherapy. The work was done in mice, so it is not yet shown in patients.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | mTOR inhibition augments antitumor immune effector response by reprogramming the TP53-mutant, immune-cold HNSCC tumor microenvironment NAT2026 In mouse models of TP53-mutant head and neck cancer, everolimus reprogrammed the immune-cold tumour environment and boosted anti-tumour T cell activity; Nathan was senior and corresponding author. |
Co-authors in the Atlas
People with a profile here who share at least one study with Cherie-Ann O. Nathan.
- J. Silvio Gutkind Showed that persistent mTOR activation exhausts epidermal stem cells and accelerates skin ageing, and targets PI3K–mTOR signalling in head-and-neck cancer, including to make tumours respond to immunotherapy
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