Arnab Mukhopadhyay
Studies how diet and gene activity interact to set lifespan in the roundworm C. elegans; his 2026 paper links loss of the mTORC2 component RICTOR to longevity on vitamin B12-rich diets through the methionine cycle and mitophagy.
National Institute of Immunology, New Delhi · Postdoctoral training, University of Massachusetts Medical School · PhD, University of Delhi
Molecular Aging Laboratory, National Institute of Immunology (New Delhi, India) ↗
Arnab Mukhopadhyay is a faculty member at the National Institute of Immunology in New Delhi, where he leads the Molecular Aging Laboratory. According to the institute’s faculty page he completed his MSc and PhD at the University of Delhi and then trained as a postdoctoral fellow at the University of Massachusetts Medical School in Worcester, USA.
His lab works on ageing biology, longevity mechanisms and diet–gene interactions, using the roundworm C. elegans. In the corpus, his 2026 Nature Communications study shows that worms lacking rict-1 (the worm version of RICTOR, a core part of mTORC2) live longer and tolerate osmotic stress better, but only on bacterial diets rich in vitamin B12; the effect needed the methionine cycle, a mitochondrial enzyme that makes succinate, and mitophagy. It is a worm result and does not by itself say whether inhibiting mTORC2 would extend lifespan in mammals.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | RICTOR regulates an interspecies crosstalk that influences longevity through a methionine cycle-mitophagy axis MOT2026 In C. elegans, loss of rict-1/RICTOR extended lifespan on B12-rich diets via a methionine cycle–succinate–mitophagy axis (worm genetics only). |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Arnab Mukhopadhyay.
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- Simran Motwani First author of the 2026 Nature Communications study on RICTOR, vitamin B12 diets and longevity in C. elegans.
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