Antje S. Löffler
Cell biologist who worked in Björn Stork's group on how the autophagy kinase ULK1 talks back to the energy sensor AMPK
Institute of Molecular Medicine I, Heinrich Heine University Düsseldorf (papers to 2015) · Department of Internal Medicine I, University of Tübingen (at the time of LOF2011)
In LOF2011, Antje Löffler was first author of the study from Björn Stork's group at the University of Tübingen showing that ULK1, the kinase that starts autophagy, phosphorylates and inhibits AMPK, the energy sensor that normally switches ULK1 on. The result is a negative feedback loop: once autophagy has been triggered, ULK1 turns down the signal that started it. This matters for the mTOR field because AMPK and mTORC1 both act on ULK1 from opposite sides, so a loop back to AMPK changes how the whole system responds to starvation. The work was done in cell and biochemical experiments.
Löffler appears on seven PubMed papers from 2011 to 2015, all on autophagy signalling with Stork and Sebastian Wesselborg, first in Tübingen and then at the Institute of Molecular Medicine I of Heinrich Heine University Düsseldorf. They include a 2015 study mapping the ULK1-binding site on the autophagy protein ATG13. No later papers or institutional page were found, so the affiliation shown is the last one on these papers.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2011 | M | Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop LOF2011 First author: showed that ULK1 phosphorylates AMPK and inhibits it, a negative feedback loop in autophagy signalling. |
Co-authors in the Atlas 3
People with a profile here who share at least one study with Antje S. Löffler.
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- Björn Stork Heisenberg Professor for the molecular biology of cellular stress responses at Heinrich Heine University Düsseldorf, who studies the ULK1 complex, the switch that starts autophagy, and how it is wired to the energy sensor AMPK and to mTOR
- Dario R. Alessi Co-discovered PDK1, the master kinase that switches on Akt and related AGC kinases, and showed that mTORC2 activates the kinase SGK1
- Mondira Kundu Physician-scientist who works out what the autophagy-initiating kinases ULK1 and ULK2 actually do when a cell runs short of fuel
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