Angelia Szwed
Lead author, from Estela Jacinto's Rutgers lab, of a long Physiological Reviews article on how the two mTOR complexes are controlled and what they do in metabolism
Jacinto Lab, Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University (at the time of the 2021 review)
Angelia Szwed is the first author of SZW2021, a review in Physiological Reviews written with Eugene Kim and Estela Jacinto at Rutgers. mTOR, the cell's central growth kinase, works inside two different protein complexes. mTORC1 reads nutrients and switches on the making of proteins, fats and nucleotides. mTORC2 responds mostly to growth factors and helps control sugar uptake, survival and the cell's skeleton. The review explains how each complex is switched on and off and what each one does to metabolism, with examples from cancer, immune cells, diabetes and obesity, brain disease and ageing.
For a student, a review of this kind is a map of the field. It is useful for seeing how the many single findings fit together, but it reports other people's experiments and does not add new data of its own.
The Jacinto lab website lists the review on a page for Szwed. PubMed shows no other papers under this name with an mTOR or Rutgers link, and no official profile was found, so the position shown is the affiliation on the review.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2021 | R | Regulation and metabolic functions of mTORC1 and mTORC2 SZW2021 First author of a Physiological Reviews article on how mTORC1 and mTORC2 are regulated and how they control metabolism. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Angelia Szwed.
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- Estela Jacinto Co-discovered mammalian mTORC2 as a postdoc in Michael Hall's lab, showing that it controls the actin cytoskeleton and is insensitive to rapamycin. Her Rutgers lab, with Bing Su's group, was among those that found SIN1 holds mTORC2 together and studies how both mTOR complexes control metabolism
Every researcher with a profile →
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