Adrian L. Harris
Medical oncologist who studies hypoxia, tumour blood-vessel growth and the metabolic response of breast cancer cells.
University of Oxford · Emeritus Professor of Medical Oncology · First Professor of Medical Oncology at Oxford (1989–2017) · Emeritus
Portrait: University of Oxford, Department of Oncology
Adrian Harris is an emeritus professor of medical oncology at the University of Oxford. His Oxford page says he became Professor of Clinical Oncology at Newcastle-upon-Tyne in 1982 and in 1989 the first Professor of Medical Oncology at Oxford, a post he held until 2017. He directed the Cancer Research UK Molecular Oncology Laboratories at the Weatherall Institute of Molecular Medicine. His research focus is hypoxia, tumour angiogenesis and metabolism.
The 2016 Cell Metabolism review in the Atlas was written with Deborah Goberdhan and Clive Wilson, both at Oxford. It discusses how mTORC1 senses amino acids, and argues that transporters in different cell compartments, including lysosomes and the Golgi apparatus, mark the places where mTORC1 is switched on.
The authors propose that different amino acids in different compartments may activate different mTORC1 complexes, which could have different drug sensitivities and jobs. This is a proposal, not a final answer.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2016 | R | Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot GOB2016 Review proposing that amino-acid transporters on lysosomes, endosomes and the Golgi mark sites of mTORC1 activation and may define distinct mTORC1 complexes; Harris was senior author. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Adrian L. Harris.
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- Deborah C. I. Goberdhan Oxford cell biologist who studies how amino acid transporters and the cell's secretory compartments control growth signalling, often using the fruit fly, and who argued that intracellular transporters mark where mTORC1 is switched on
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