Pathway link ULK1-AMPK

ULK1 ⊣ AMPK

ULK1 inhibits AMPK.

ULK1 tags AMPK back and calms it down – a feedback loop that keeps cleanup from running out of control.

ULK1 phosphorylates AMPK back, damping the signal that activated it - a negative feedback loop that stops autophagy running away.

The conditions it holds under

One study in human cells and mouse (LOF2011). A single study. The feedback loop is shown in cell models, and the relation in the other direction (AMPK-ULK1) is contested.

Closes a loop rather than acting as a one-way arrow; steady-state behaviour depends on the relative strength of both directions.

Time it takes

minutes

Step

direct (one molecule acts on the other)

Measured in

mammalian cells

Where in the cell

cytosol

Reaches people?

plausible in people, not shown directly

How settled

settled in the literature

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“Inhibits” describes the effect on the target's activity, not on how much of it there is.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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