Pathway link TBK1-FNIP1

TBK1 ⊣ FLCN / FNIP1/2

TBK1 inhibits FLCN / FNIP1/2.

TBK1 tags FNIP1, which turns FLCN off and lets TFEB escape mTORC1's grip.

On the stressed lysosome, TBK1 phosphorylates FNIP1 at S296. This switches the FLCN-FNIP complex off, so mTORC1 can no longer hold TFEB in the cytoplasm and TFEB moves into the nucleus. ULK1 can do the same (ULK1-FNIP1).

The conditions it holds under

Human cell lines and ATP6V1B2-mutant follicular lymphoma samples (ESP2026); a nutrient-independent lysosomal-stress route. Single study, not yet replicated.

A parallel input to TFEB, not a refutation of canonical TFEB control by mTORC1 (MTORC1-TFEB): it acts by removing FLCN, which mTORC1 needs in order to reach TFEB.

Time it takes

minutes

Step

direct (one molecule acts on the other)

Measured in

human cells

Where in the cell

lysosome

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“Inhibits” describes the effect on the target's activity, not on how much of it there is.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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