Pathway link SAMTOR-GATOR1

SAMTOR → GATOR1

SAMTOR activates GATOR1.

When methionine is low, SAMTOR teams up with GATOR1 to help keep mTORC1 switched off.

Methionine-starved SAMTOR binds the GATOR1-KICSTOR complex and helps it keep mTORC1 off.

The conditions it holds under

One biochemical study in human cells (GU2017). A single study in cell culture; the consensus is emerging, not settled.

Time it takes

seconds

Step

direct (one molecule acts on the other)

Measured in

human cells

Where in the cell

lysosome

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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