Pathway link PRAS40-MTORC1
PRAS40 mTORC1
PRAS40 inhibits mTORC1.
Untagged PRAS40 sits inside mTORC1 and blocks it, like a built-in plug.
The conditions it holds under
Human cell biochemistry and a cryo-EM structure (SAN2007, YAN2017). Shows the plug mechanism in cells and in structure; its effect in whole animals and in people is not tested here.
- Time it takes
- seconds
- Step
- direct (one molecule acts on the other)
- Measured in
- mammalian cells
- Where in the cell
- lysosome
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2007 | M | PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinaseSAN2007 Identified PRAS40 as the missing insulin-controlled brake INSIDE mTORC1. When insulin is absent PRAS40 clamps the complex shut; insulin makes Akt phosphorylate PRAS40, releasing the brake so Rheb can fully switch mTORC1 on. Explained how hormone signals set the exact strength of mTORC1 activity. |
| 2017 | M | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40YAN2017 Structures reveal how RHEB allosterically activates and PRAS40 inhibits mTORC1. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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