Oliver's mTOR Atlas Evidence Platform
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Pathway link MTORC1-SAM

mTORC1 S-adenosylmethionine (SAM)

mTORC1 activates S-adenosylmethionine (SAM).

mTORC1 tells the cell to make more SAM.

Active mTORC1, acting through the transcription factor c-MYC, raises production of MAT2A, the enzyme that makes SAM, so a growing cell makes more of its main methyl donor.

The conditions it holds under

Human cell lines and mouse xenograft tumours; acts through c-MYC on MAT2A. Together with SAM-SAMTOR this forms a loop whose behaviour in normal tissue is untested. Single study.

Time it takes
hours
Step
indirect (through steps not drawn here)
Measured in
human cells, mouse xenograft
Where in the cell
nucleus
Reaches people?
plausible in people, not shown directly
How settled
emerging, few independent studies

Studies behind it

YearEvidenceStudy
2021 M mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesisVIL2021 SAMTOR (GU2017) showed the cell can sense S-adenosylmethionine and report it to mTORC1. This study runs the arrow the other way: mTORC1 controls how much SAM the cell makes. Downstream of mTORC1, c-MYC binds intron 1 of MAT2A and raises expression of the enzyme that produces SAM, the cell's main methyl donor; mTORC1 separately increases the protein level of WTAP, the regulatory subunit of the m6A RNA methyltransferase complex. Together these raise m6A methylation of mRNA, which primes the translation machinery for growth. Blocking MAT2A lowers SAM, m6A, protein synthesis rate and tumor growth.

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by
No researcher outside the project has checked this link yet.
Curator sign-off
Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
Curated by
Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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