Pathway link MTORC1-PROSTATE

mTORC1 → Prostate cancer

mTORC1 activates Prostate cancer.

Blocking mTOR reversed early, pre-cancerous prostate changes in mice caused by an overactive growth signal.

Blocking mTOR reversed Akt-driven pre-cancerous prostate lesions in mice, showing the growth was mTORC1-dependent and reversible.

The conditions it holds under

Scope: the lesion was prostatic intraepithelial neoplasia, a pre-cancerous stage, driven by transgenic human AKT1 in mice, and the drug (RAD001) inhibits mTORC1 allosterically. Mouse only in this corpus. Not a demonstration in established prostate cancer.

Time it takes

long exposure (days to weeks)

Step

indirect (through steps not drawn here)

Measured in

mouse

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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